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In one of the largest prospective studies involving142,902 professionals and nurses, the incidence rate wasestimated to be 18.6/100,000 person-years (43.2 for malesand 10.7 for females, respectively) (Chen et al., 2003).Furthermore, there appears to be a decreased incidenceof PD in black populations, and some have postulatedthat melanin may have a neuroprotective function.
In the united States, theOccupational Safety and Health Act of 1970, which createdboth the Occupational Safety and Health Administration(OSHA) and the National Institute for Occupational Safetyand Health (NIOSH), allowed for greater oversight and reg-ulation of occupational exposures and furthered the field ofoccupational and environmental medicine in the unitedStates. The risk associ-ated with immunomodulators and biologic medications remains a topic of controversy.
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